Data di Pubblicazione:
2010
Citazione:
Urinary profiles to assess polycyclic aromatic hydrocarbons exposure in coke-oven workers / L. Campo, F. Rossella, S. Pavanello, D. Mielzynska, E. Siwinska, L. Kapka, P.A. Bertazzi, S. Fustinoni. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 192:1(2010), pp. 72-78. [10.1016/j.toxlet.2008.12.018]
Abstract:
Aim of the study was the assessment of exposure of coke-oven workers to polycyclic aromatic hydrocarbons(PAHs) by determination of urinary profiles of hydroxylated and unmetabolized PAHs. Fifty-five Polish coke-oven workers were investigated by measurement of 12 hydroxylated metabolites of PAHs(OHPAHs) (1-, 2-hydroxynaphthalene; 2-, 9-hydroxyfluorene; 1-, 2-, 3-, 4-, 9-hydroxyphenanthrene; 1-hydroxyypyrene, 6-hydroxychrysene and 3-hydroxybenzo[a]pyrene) and 13 unmetabolized PAHs (UPAHs)(from naphthalene to benzo[a]pyrene), in spot urine samples collected at the end of the workshift.
U-PAHs with four or less rings were detected in all samples. In particular, median levels for urinary naphthalene, phenanthrene, pyrene, chrysene and benz[a]anthracene were 0.806, 0.721, 0.020, 0.032 and 0.035 µg/L. OHPAHs up to 1-hydroxypyrene were found in all samples, while high molecular-weight
OHPAHs were always below quantification limit. Median level of 1-hydroxyypyrene was 15.4 µg/L. In all subjects significant correlations betweenOHPAHsand U-PAHswere observed (0.27 < r < 0.70, p < 0.01). Our
results suggest that both hydroxylated metabolites and unmetabolized PAHs in urine are useful biomarkers of exposure to PAHs. Moreover, the simultaneous determination of several biomarkers permits to obtain specific excretion profiles that might help in exposure characterization and in better defining the excretion patterns.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biological monitoring; Coke-oven workers; PAH; Urine
Elenco autori:
L. Campo, F. Rossella, S. Pavanello, D. Mielzynska, E. Siwinska, L. Kapka, P.A. Bertazzi, S. Fustinoni
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