Palladium-assisted multicomponent synthesis of 2-aryl-4 aminoquinolines and 2-aryl- 4-amino[1,8]naphthyridines
Articolo
Data di Pubblicazione:
2005
Citazione:
Palladium-assisted multicomponent synthesis of 2-aryl-4 aminoquinolines and 2-aryl- 4-amino[1,8]naphthyridines / G. Abbiati, A. Arcadi, V. Canevari, L. Capezzuto, E. Rossi. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 70:16(2005 Aug), pp. 6454-6460. [10.1021/jo050882q]
Abstract:
A palladium-mediated multicomponent domino reaction leading to 2-aryl-4-amino-quinolines and
2-aryl-4-amino[1,8]naphthyridines is reported. The scope of the reaction was examined using carbon
monoxide, two 2-ethynyl-arylamines, four aryl iodides, and 10 primary amines as substrates. The
selection of the appropriate catalytic system was achieved testing several palladium/phosphine
systems and overrides previously reported drawbacks associated with the use of primary amines
in related reactions. Moreover several features concerning the role of both palladium [(0) and (II)]
and phosphines are reported.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Abbiati, A. Arcadi, V. Canevari, L. Capezzuto, E. Rossi
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