Role of long non-coding RNAs in adipogenesis : State of the art and implications in obesity and obesity-associated diseases
Articolo
Data di Pubblicazione:
2021
Citazione:
Role of long non-coding RNAs in adipogenesis : State of the art and implications in obesity and obesity-associated diseases / F. Rey, V. Urrata, L. Gilardini, S. Bertoli, V. Calcaterra, G.V. Zuccotti, R. Cancello, S. Carelli. - In: OBESITY REVIEWS. - ISSN 1467-7881. - (2021 Jan 14). [Epub ahead of print] [10.1111/obr.13203]
Abstract:
Obesity is an evolutionary, chronic, and relapsing disease that consists of a pathological accumulation of adipose tissue able to increase morbidity for high blood pressure, type 2 diabetes, metabolic syndrome, and obstructive sleep apnea in adults, children, and adolescents. Despite intense research over the last 20 years, obesity remains today a disease with a complex and multifactorial etiology. Recently, long non-coding RNAs (lncRNAs) are emerging as interesting new regulators as different lncRNAs have been found to play a role in early and late phases of adipogenesis and to be implicated in obesity-associated complications onset. In this review, we discuss the most recent advances on the role of lncRNAs in adipocyte biology and in obesity-associated complications. Indeed, more and more researchers are focusing on investigating the underlying roles that these molecular modulators could play. Even if a significant number of evidence is correlation-based, with lncRNAs being differentially expressed in a specific disease, recent works are now focused on deeply analyzing how lncRNAs can effectively modulate the disease pathogenesis onset and progression. LncRNAs possibly represent new molecular markers useful in the future for both the early diagnosis and a prompt clinical management of patients with obesity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
adipogenesis; lncRNAs; metabolic diseases; obesity
Elenco autori:
F. Rey, V. Urrata, L. Gilardini, S. Bertoli, V. Calcaterra, G.V. Zuccotti, R. Cancello, S. Carelli
Link alla scheda completa:
Link al Full Text: