A model of DNA damage response activation at stalled replication forks by SPRTN

Articolo

Data di Pubblicazione:

2019

Citazione:

A model of DNA damage response activation at stalled replication forks by SPRTN / C. Bruhn, M. Foiani. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 10:1(2019), pp. 5671.1-5671.3. [10.1038/s41467-019-13610-7]

Abstract:

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

Tipologia IRIS:

01 - Articolo su periodico

Keywords:

Cell Cycle; Checkpoint Kinase 1; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Genomic Instability; Humans

Elenco autori: