Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

Articolo
Data di Pubblicazione:
2012
Citazione:
Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs) / A. Curcio, R. Marotta, D. Palumberi, A. Falqui, T. Pellegrino. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:18(2012 Jan), pp. 2400-2402. [10.1039/c2cc17223b]
Abstract:
We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Curcio, R. Marotta, D. Palumberi, A. Falqui, T. Pellegrino
Autori di Ateneo:
FALQUI ANDREA ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/778720

Aree Di Ricerca

Settori


Settore FIS/03 - Fisica della Materia