Paradoxical fall in proteinuria during pregnancy in an LCAT-deficient patient—A case report
Articolo
Data di Pubblicazione:
2018
Citazione:
Paradoxical fall in proteinuria during pregnancy in an LCAT-deficient patient—A case report / E.V. Hanna, S. Simonelli, S. Chamney, A. Ossoli, R.N. Mullan. - In: JOURNAL OF CLINICAL LIPIDOLOGY. - ISSN 1933-2874. - 12:5(2018), pp. 1151-1156. [10.1016/j.jacl.2018.06.006]
Abstract:
A 29-year-old lady was diagnosed with lecithin:cholesterol acyltransferase (LCAT) deficiency having presented with bilateral corneal clouding, severely reduced high density lipoproteins cholesterol, and proteinuria. She is a compound heterozygote with two LCAT gene mutations, one of which is novel, c.321C>A in exon 3. Surprisingly, the level of proteinuria significantly improved during pregnancy, despite stopping the angiotensin-converting enzyme inhibitor. However, LCAT concentration and activity remained identical during pregnancy and postpartum. Her pregnancy was complicated by rising triglyceride levels from the second trimester requiring treatment with omega-3 fatty acid and fenofibrate. In the last trimester, a further complication arose when she became hypertensive and proteinuria worsened. She was diagnosed with pre-eclampsia and had an emergency cesarean section at 39 weeks delivering a healthy baby. This case adds to the knowledge of the pathophysiology of LCAT deficiency during pregnancy and will be useful in future patient management.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
LCAT deficiency; Lipoprotein X; Pregnancy; Proteinuria; Adult; Female; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Pregnancy; Pregnancy Complications; Proteinuria; Triglycerides
Elenco autori:
E.V. Hanna, S. Simonelli, S. Chamney, A. Ossoli, R.N. Mullan
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