How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study
Articolo
Data di Pubblicazione:
2020
Citazione:
How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study / M. Gacci, W. Artibani, P. Bassi, F. Bertoni, S. Bracarda, A. Briganti, G. Carmignani, L. Carmignani, G. Conti, R. Corvò, C. De Nunzio, F. Fusco, P. Graziotti, I. Greco, S. Maggi, S.M. Magrini, V. Mirone, R. Montironi, G. Morgia, G. Muto, M. Noale, S. Pecoraro, A. Porreca, U. Ricardi, E. Russi, G. Russo, A. Salonia, A. Simonato, S. Serni, D. Tomasini, A. Tubaro, V. Zagonel, G. Crepaldi. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2020). [Epub ahead of print] [10.1007/s00345-020-03350-5]
Abstract:
Purpose: Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy.
Methods: The data from two independent Italian multicenter projects, the MIRROR-SIU/LUNA (started in 2007, holding data of 890 patients) and the Pros-IT-CNR project (started in 2014, with data of 692 patients), were compared. Differences in patients' characteristics were evaluated. Multivariable logistic regression models were used to identify characteristics associated with robot-assisted (RA) procedure, nerve sparing (NS) approach, and lymph node dissection (LND).
Results: The two cohorts did not differ in terms of age and prostate-specific antigen (PSA) levels at biopsy. Patients enrolled in the Pros-IT-CNR project more frequently were submitted to RA (58.8% vs 27.6%, p < 0.001) and NS prostatectomy (58.4% vs. 52.9%, p = 0.04), but received LND less frequently (47.7% vs. 76.7%, p < 0.001), as compared to the MIRROR-SIU/LUNA patients. At multivariate logistic models, Lower Gleason Scores (GS) and PSA levels were significantly associated with RA prostatectomy in both cohorts. As for the MIRROR-SIU/LUNA data, clinical T-stage was a predictor for NS (OR = 0.07 for T3, T4) and LND (OR = 2.41 for T2) procedures. As for Pros-IT CNR data, GS ≥ (4 + 3) and positive cancer cores ≥ 50% were decisive factors both for NS (OR 0.29 and 0.30) and LND (OR 7.53 and 2.31) strategies.
Conclusions: PCa management has changed over the last decade in Italian centers: RA and NS procedures without LND have become the methods of choice to treat newly medium-high risk diagnosed PCa.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Lymph node dissection; MIRROR SIU/LUNA study; Nerve sparing; Pros-IT CNR study; Prostate cancer; Robotic procedures
Elenco autori:
M. Gacci, W. Artibani, P. Bassi, F. Bertoni, S. Bracarda, A. Briganti, G. Carmignani, L. Carmignani, G. Conti, R. Corvò, C. De Nunzio, F. Fusco, P. Graziotti, I. Greco, S. Maggi, S. Maria Magrini, V. Mirone, R. Montironi, G. Morgia, G. Muto, M. Noale, S. Pecoraro, A. Porreca, U. Ricardi, E. Russi, G. Russo, A. Salonia, A. Simonato, S. Serni, D. Tomasini, A. Tubaro, V. Zagonel, G. Crepaldi, W. Artibani, P. Bassi, S. Bracarda, G. Natale Conti, R. Corvò, G. Crepaldi, A. Porreca, P. Graziotti, S. Maggi, V. Mirone, R. Montironi, M. Noale, E. Russi, F. Bertoni, M. Gacci, S. Maria Magrini, G. Muto, S. Pecoraro, U. Ricardi, A. Tubaro, V. Zagonel, A. Rita Alitto, E. Ambrosi, A. Antonelli, C. Aristei, F. Bardari, L. Bardoscia, S. Barra, S. Bartoncini, U. Basso, C. Becherini, R. Bellavita, F. Bergamaschi, S. Berlingheri, A. Berruti, M. Borghesi, R. Bortolus, V. Borzillo, D. Bosetti, G. Bove, P. Bove, M. Brausi, A. Bruni, G. Bruno, E. Brunocilla, A. Buffoli, M. Buglione, C. Buttigliero, G. Cacciamani, M. Caldiroli, G. Cardo, G. Carmignani, G. Carrieri, E. Castelli, E. Castrezzati, G. Catalano, S. Cattarino, F. Catucci, D. Cavallini Francolini, O. Ceccarini, A. Celia, F. Chiancone, T. Chini, C. Cianci, A. Cisternino, D. Collura, F. Corbella, M. Corinti, P. Corsi, F. Cortese, L. Corti, N. Decosimo, O. Cristiano, D. Rolando, L. Da Pozzo, D. D'Agostino, C. D'Elia, M. Dandrea, M. De Angelis, P. De Angelis, O. DE COBELLI, B. De Concilio, A. De Lisa, S. De Luca, A. De Stefani, C. Lucrezia Deantoni, C. Degli Esposti, A. Destito, B. Detti, N. Di Muzio, A. Di Stasio, C. Di Stefano, D. Di Trapani, G. Difino, S. Falivene, G. Farullo, P. Fedelini, I. Ferrari, F. Ferraù, M. Ferro, A. Fodor, F. Fontana, F. Francesca, G. Francolini, P. Frata, G. Frezza, P. Gabriele, M. Galeandro, E. Garibaldi, P. Giovanni Gennari, A. Gentilucci, A. Giacobbe, L. Giussani, G. Giusti, P. Gontero, A. Guarneri, C. Guida, A. Gurioli, D. Huqi, C. Imbimbo, G. Ingrosso, C. Iotti, C. Italia, P. La Mattina, R. La Rocca, E. Lamanna, L. Lastrucci, G. Lazzari, F. Liberale, G. Liguori, R. Lisi, F. Lohr, R. Lombardo, J. Aj Lovisolo, G. Mario Ludovico, N. Macchione, F. Maggio, M. Malizia, G. Manasse, G. Mandoliti, G. Mantini, L. Marafioti, L. Marciello, A. Mario Marconi, A. Martilotta, S. Marzano, S. Masciullo, G. Maso, A. Massenzo, E. Mazzeo, L. Mearini, S. Medoro, R. Molè, G. Monesi, E. Montanari, F. Montefiore, G. Montesi, G. Morgia, G. Moro, G. Muscas, D. Musio, P. Muto, G. Muzzonigro, G. Napodano, C. Luigi Augusto Negro, M. Nidini, M. Ntreta, M. Orsatti, C. Palazzolo, I. Palumbo, A. Parisi, P. Parma, N. Pavan, M. Pericolini, F. Pinto, A. Pistone, V. Pizzuti, A. Platania, C. Polli, G. Pomara, E. Ponti, A. Benito Porcaro, F. Porpiglia, D. Pugliese, A. Pycha, G. Raguso, A. Rampini, D. Franco Randone, V. Roboldi, M. Roscigno, M. Paola Ruggieri, G. Ruoppo, R. Sanseverino, A. Santacaterina, M. Santarsieri, R. Santoni, S. Scagliarini, G. Vittorio Scagliotti, M. Scanzi, M. Scarcia, R. Schiavina, A. Sciarra, C. Sciorio, T. Scolaro, S. Scuzzarella, O. Selvaggio, A. Serao, S. Serni, M. Andrea Signor, M. Silvani, G. Silvano, F. Silvestris, C. Simeone, V. Simone, G. Spagnoletti, M. Giulio Spinelli, L. Squillace, V. Tombolini, M. Toninelli, L. Triggiani, A. Trinchieri, L. Trodella, E. Luca, L. Trodella, C. Trombetta, L. Tronnolone, M. Tucci, D. Urzì, R. Valdagni, M. Valeriani, M. Vanoli, E. Vitali, A. Volpe, S. Zaramella, G. Zeccolini, G. Zini, F. Acanfora, E. Aiello, S. Alchiede, V. Altieri, C. Anceschi, F. Aragona, W. Artibani, F. Balloni, E. Barasolo, G. Barba, R. Bartoletti, P. Bassi, B. Bigazzi, E. Belgrano, S. Salvatore, M. Battaglia, L. Bellei, A. Bettin, G. Bianchi, L. Bombieri, T. Brancato, G. Breda, A. Briganti, S. Caggiano, A. Calabrò, M. Caldironi, B. Campo, S. Capobianco, F. Capparelli, A. Carbone, D. Carlo, G. Carmignani, G. Catalano, F. Catanzaro, F. Ciaraldi, V. Cicalese, A. Cisternino, C. Corbu, S. Cosciani Cunico, V. Cosentino, A
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