Data di Pubblicazione:
2019
Citazione:
The Lpt ABC transporter for lipopolysaccharide export to the cell surface / P. Sperandeo, A.M. Martorana, A. Polissi. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - 170:8(2019 Nov), pp. 366-373.
Abstract:
The surface of the outer membrane of Gram-negative bacteria is covered by a tightly packed layer of lipopolysaccharide molecules which provide a barrier against many toxic compounds and antibiotics. Lipopolysaccharide, synthesized in the cytoplasm, is assembled in the periplasmic leaflet of the inner membrane where the intermembrane Lpt system mediates its transport to the cell surface. The first step of lipopolysaccharide transport is its extraction from the outer leaflet of inner membrane powered by the atypical LptB2FGC ABC transporter. Here we review latest advances leading to understanding at molecular level how lipopolysaccharide is transported irreversibly to the outer membrane.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ABC transporter; LPS transport; Lpt machinery; Outer membrane biogenesis; ATP-Binding Cassette Transporters; Bacterial Outer Membrane Proteins; Biological Transport; Cell Membrane; Escherichia coli; Lipopolysaccharides; Protein Conformation
Elenco autori:
P. Sperandeo, A.M. Martorana, A. Polissi
Link alla scheda completa: