Data di Pubblicazione:
2020
Citazione:
Trends in the production methods of orodispersible films / U.M. Musazzi, G.M. Khalid, F. Selmin, P. Minghetti, F. Cilurzo. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 576(2020 Feb 25), pp. 118963.1-118963.10. [10.1016/j.ijpharm.2019.118963]
Abstract:
Interest in orodispersible films (ODF) is growing day-by-day, since this dosage form overcomes some therapeutic obstacles, such as impaired swallowing, and offers several benefits, such as the possibility to adapt the dosing requirements for a subset of patients. As a consequence, technologies to produce ODF have risen attention for possible applications in the development of patient-centric formulations. This review critically discusses current trends in the technology platforms proposed to manufacture ODF, including the innovation and opportunities to produce very small batches in a pharmacy setting. Although the main Pharmacopoeias recommend testing customized dosage forms for quality assurance, pharmaceutical assays are a matter of debate due to the complexity and high cost of conventional methods. Alternatively, non-disruptive online analytic methods can be proposed to assay ODF properties, above all to assure the uniformity of drug content.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
drug printing; flexographic printing; individualized medicine; orodispersible films; solvent casting
Elenco autori:
U.M. Musazzi, G.M. Khalid, F. Selmin, P. Minghetti, F. Cilurzo
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