Il recettore H4 dell’istamina: possibile target di nuovi farmaci per il trattamento delle allergie croniche

The selective recruitment and activation of eosinophils and mastocytes into the tissue from peripheral blood, represents a crucial pathogenetic moment which predisposes the chronic trend of allergic diseases. The results reported in this original article are the direct prove that chemotaxis of both eosinophils and mastocytes may be mediated also by histamine via activation of specific histamine H4 receptor subtype which is expressed on the surface of these proinflammatory cells. Therefore, this histamine H4 receptor subtype is considered a new pharmacological target leading to development of potent highly selective antagonists with considerably therapeutical potential in allergic diseases