Farmacocinetica della flumequina nella capra. Dati preliminari

Flumequine kinetics, administered intravenously (i.v.) and intramuscularly (i.m.) at 20 mg.kg-1, was investigated in 6 healthy goats, and the kinetic parameters obtained related to minimal inhibitory concentrations (MIC90) reported in literature. After i.v. injection, flumequine distributed rapidly (t1/2α = 0.87 ± 0.15 h) but was eliminated slowly (t1/2β = 7.12 ± 1.27 h). After i.m. administration, peak serum level (Cmax= 7.40±0.5 μg.mL-1) and bioavailability (>90%) of the drug indicate that flumequine could have a good efficacy against systemic infections sustained by susceptible microorganisms.