Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.