Molecular typing of Burkholderia cepacia complex isolated from patients attending an Italian Cystic Fibrosis Centre
Articolo
Data di Pubblicazione:
2018
Citazione:
Molecular typing of Burkholderia cepacia complex isolated from patients attending an Italian Cystic Fibrosis Centre / A. Teri, S. Sottotetti, A. Biffi, D. Girelli, M. D'Accico, M. Arghittu, C. Colombo, F. Corti, G. Pizzamiglio, L. Cariani. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 41:2(2018 Apr), pp. 141-144.
Abstract:
Bacteria from the Burkholderia cepacia complex (Bcc) are capable of causing severe infections in patients
with cystic fibrosis (CF). Bcc infection is often extremely difficult to treat due to its intrinsic resistance
to multiple antibiotics. In addition, it seems to speed up the decline of lung function and is considered a
contraindication for lung transplantation in CF. This study investigates the species of the Bcc strains recovered from chronically infected CF subjects by means of: isolation, identification methods and complete recA nucleotide sequences of 151 samples. Molecular typing showed that B. cenocepacia III is the dominant strain found in the group of subjects
being treated at the Milan CF Centre (Italy) and that the infection is chronically maintained by the same
species. Defining species by means of molecular analysis yields important information for the clinician in order to
establish the most appropriate therapy and implement correct measures for prevention of transmission
among CF subjects.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Burkholderia cenocepacia; Burkholderia cepacia complex; Cystic fibrosis; Genomovar; Molecular typing; recA; Burkholderia Infections; Burkholderia cepacia complex; Cystic Fibrosis; Humans; Italy; Pharmacogenomic Variants
Elenco autori:
A. Teri, S. Sottotetti, A. Biffi, D. Girelli, M. D'Accico, M. Arghittu, C. Colombo, F. Corti, G. Pizzamiglio, L. Cariani
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