A convenient two step transformation of tyrosine into the antihypertensive amino acid (S)-4-hydroxy-3-hydroxymethylphenylalanine
Articolo
Data di Pubblicazione:
2004
Citazione:
A convenient two step transformation of tyrosine into the antihypertensive amino acid (S)-4-hydroxy-3-hydroxymethylphenylalanine / P. Allevi, R. Cribiù, M. Anastasia. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:8(2004 Apr 19), pp. 1355-1358. [10.1016/j.tetasy.2004.02.031]
Abstract:
Treatment of tyrosine with paraformaldehyde and catalytic amounts of p-toluenesulfonic acid, at reflux in toluene, directly generates benzyl (S)-4-(4H-1,3-benzodioxin-6-ylmethyl)-5-oxo-1,3-oxazolane-3-carboxylate, which on treatment with boron trichloride in dichloromethane, affords (S)-4-hydroxy-3-hydroxymethylphenylalanine.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
tyrosine homologue ; antihypertensive ; Parkinson
Elenco autori:
P. Allevi, R. Cribiù, M. Anastasia
Link alla scheda completa: