Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review
Articolo
Data di Pubblicazione:
2019
Citazione:
Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review / M. Del Fabbro, S. Panda, S. Taschieri. - In: JOURNAL OF EVIDENCE BASED DENTAL PRACTICE. - ISSN 1532-3382. - (2019). [Epub ahead of print] [10.1016/j.jebdp.2018.11.003]
Abstract:
Purpose: The purpose of this study was to determine if the adjunctive use of plasma rich in
growth factors in post-extraction sites could be beneficial in terms of hard/soft tissue healing and
patient’s comfort.
Materials and Methods: An electronic search was performed on MEDLINE, EMBASE, Scopus,
and CENTRAL. Only controlled clinical trials or randomized clinical trials that used plasma rich
in growth factors in the test group were included. The primary outcomes were: pain assessment,
complications and adverse events; secondary outcomes were hard tissue healing, bone
remodelling, soft tissue healing.
Results: Eight comparative studies (5 RCTs) were included. Four studies had a split-mouth
design. 614 teeth were extracted in 338 patients. Only qualitative analysis could be done.
Postoperative pain and the incidence of complications like alveolar osteitis was consistently
lower in the test group. Hard tissue healing, evaluated by clinical, radiographic, histological and
histomorphometric technique showed results significantly better for the test group in almost all
studies. Better epithelization, keratinized tissue thickness and healing score were also reported.
Conclusion: Plasma rich in growth factors may bring advantages in some relevant clinical and
radiographic outcomes following tooth extraction, such as bone density and soft tissue healing.
It could also represent a useful tool for reducing adverse events, complications and patients’
discomfort, however still not quantifiable.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Platelet rich in growth factors; Post extraction healing; Systematic review
Elenco autori:
M. Del Fabbro, S. Panda, S. Taschieri
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