Flow chemistry, organocatalysis and 3D-printing : valuable tools in the synthesis of chiral compounds

Recently developed organocatalytic stereoselective transformations using polymer-based packed bed and catalytic reactors will be presented. Furthermore, the use of different bifunctional chiral metal-free catalysts in micro- and mesofluidic devices will be described. Metal-free stereoselective additions of activated nucleophiles tonitrostyrenes were investigated under continuous-flow conditions in microreactors. The potential of this flow chemistry approach was demonstrated by the successful synthesis of an advanced intermediate for the preparation of the GABAB receptor agonist Baclofen and other Active Pharmaceutical Ingredients (APIs) such as (S)-Pregabalin and (S)-Warfarin.