Field evaluation of the efficacy and the safety of a combination of oxantel/pyrantel/praziquantel in the treatment of naturally acquired gastrointestinal nematode and/or cestode infestations in dogs in Europe
Articolo
Data di Pubblicazione:
2007
Citazione:
Field evaluation of the efficacy and the safety of a combination of
oxantel/pyrantel/praziquantel in the treatment of naturally acquired
gastrointestinal nematode and/or cestode infestations in dogs in Europe / E. Grandemange, E. Claerebout, C. Genchi, M. Franc. - In: VETERINARY PARASITOLOGY. - ISSN 0304-4017. - 145:1/2(2007), pp. 94-99. [10.1016/j.vetpar.2006.11.013]
Abstract:
In five multicentre field trials, the efficacy and safety of a combination of
oxantel/pyrantel/praziquantel (Dolpac((R)), Vetoquinol SA) in the treatment of
naturally acquired gastrointestinal nematode and/or cestode infestation in dogs
was evaluated in northern and southern Europe. Forty-eight investigators from
France, Belgium, Germany, Italy and Spain enrolled 329 dogs to be treated with
the tested combination; 235 of these dogs complied with the inclusion criteria
of the protocol and had a tested helminth identified on Day 0. A pooled analysis
was performed on each of the following helminth species: Toxocara canis,
Ancylostoma caninum, Toxascaris leonina, Trichuris vulpis, Uncinaria
stenocephala, Taenia spp. and Dipylidium caninum, which were isolated on Day 0.
The main efficacy criterion was the egg per gram (epg) percent reduction of the
nematodes and the absence of proglottids and or eggs for the cestodes. After
treatment, dogs were examined on Day 7, Day 14 and Day 21. The efficacy of the
combination against Toxocara canis was 99.1%, 98.8% and 98.9% on Day 7, Day 14
and Day 21, respectively. At the same occasions the efficacy was, respectively,
99.2%, 99.2% and 99.3% against Ancylostoma caninum, 97.3%, 97.2% and 98.4%
against Trichuris vulpis, 98.4%, 98.8% and 98.8% against Uncinaria stenocephala,
98.9%, 99.5% and 99.9% against Toxascaris leonina, 97.1%, 100% and 100% against
Dipylidium caninum and 100% against Taenia spp.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Clinical trial; Dogs; Efficacy; Intestinal helminths; Oxantel/pyrantel/praziquantel combination
Elenco autori:
E. Grandemange, E. Claerebout, C. Genchi, M. Franc
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