Lipids and Mass Spectrometry Application

During my PhD courses I focused attention on the applications of mass spectrometry in lipidomic studies. I applied mass spectrometry in several experimental models to try to observe differences in selected metabolites affected by a particular pathology. The first project performed in experimental model of impaird lipogenesis highlighted a cross talk between altered fatty acid synthesis and neuroactive steroid levels. The second project, mass spectrometry application allows to understand he effect of short-term diabetes on cholesterol metabolism. In the last project lipidomic pattern was investigated in experimental model of SCA38. Results obtained highlighted as elovl5 mutation affect phospholipids profile.