Production of non-conventional high specific activity radionuclides for biomedical, toxicological, and environmental purposes
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Data di Pubblicazione:
2006
Citazione:
Production of non-conventional high specific activity radionuclides for biomedical, toxicological, and environmental purposes / F. Groppi, M.L. Bonardi, S. Morzenti, E. Persico, L. Gini, E. Menapace, Z.B. Alfassi, B.L. Zhuikov, K. Abbas, U. Holzwarth. - Milano : Università degli Studi di Milano, 2006 Dec.
Abstract:
Low- and medium-energy accelerators and sometimes thermal nuclear reactor, allow production
of very high specific activity radionuclides (HSARNs) for biomedical, environmental, toxicological
and occupational investigations. Specific Activities of the order of GBq·μg-1 are
achieved; this means that the experiments can be carried out in the sub-nanogram range
(nanochemistry). The HSARNs allow labeling increasing amounts of different chemical forms
of toxicological or pharmacological interest, with the possibility to obtain dose vs. effect relationships
on both cell cultures and laboratory animals. In nuclear medicine, “very high” AS
- in No Carrier Added radiopharmaceuticals - are normally required to avoid undesirable
effects due to high chemical concentration of labeled species. Some labeled species are sparingly
soluble in body fluids, organs and barrier membranes; some others present toxic or
adverse effects onto humans; a low AS(NCA) means a high molar concentration and could
interfere into normal human metabolism, by inducing undesired pharmacological effects.
High-resolution HPGe c-spectrometry and b-spectrometry by liquid scintillation counting
allow determination of radionuclidic and radiochemical purities of the tracer and determination
of radiochemical yield of processing procedures. Chemical purity determination is carried
out by a range of analytical and radioanalytical techniques. Radionuclide production for
biomedical applications has been brought up in the years, at LASA, particularly in co-operation
with JRC-Ispra of EC and LENA-Pavia
Tipologia IRIS:
08 - Relazione interna o rapporto di ricerca
Elenco autori:
F. Groppi, M.L. Bonardi, S. Morzenti, E. Persico, L. Gini, E. Menapace, Z.B. Alfassi, B.L. Zhuikov, K. Abbas, U. Holzwarth
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