Pentraxin 3 is up-regulated in epithelial mammary cells during Staphylococcus aureus intra-mammary infection in goat
Articolo
Data di Pubblicazione:
2018
Citazione:
Pentraxin 3 is up-regulated in epithelial mammary cells during Staphylococcus aureus intra-mammary infection in goat / J. Filipe, G. Curone, V. Bronzo, G. Pisoni, P. Cremonesi, C. Pollera, L. Turin, D. Vigo, P. Roccabianca, M. Caniatti, P. Moroni, F. Riva. - In: COMPARATIVE IMMUNOLOGY, MICROBIOLOGY AND INFECTIOUS DISEASES. - ISSN 0147-9571. - 59:(2018 Aug), pp. 8-16. [10.1016/j.cimid.2018.08.007]
Abstract:
Pentraxin 3 is the prototypic long pentraxin and is produced by different cell populations (dendritic cells, monocytes/macrophages, endothelial cells, and fibroblasts) after pro-inflammatory stimulation. Different studies demonstrated the up-regulation of PTX3 during mastitis in ruminants, but its role is still unknown. We first investigated the conservation of PTX3 sequence among different species and its pattern of expression in a wide panel of organs from healthy goats. We studied the role modulation of PTX3 during natural and experimental mammary infection, comparing its expression in blood, milk and mammary tissues from healthy and Staphylococcus aureus infected animals. We confirmed the high conservation of the molecule among the different species. Goat PTX3 was expressed at high levels in bone marrow, mammary gland, aorta, rectum, pancreas, skin and lungs. PTX3 was up-regulated in epithelial mammary cells and in milk cells after S. aureus infection, suggesting that it represents a first line of defense in goat udder.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Pentraxin 3; Staphylococcus aureus; Intra-mammary infection; Goat; Innate immunity
Elenco autori:
J. Filipe, G. Curone, V. Bronzo, G. Pisoni, P. Cremonesi, C. Pollera, L. Turin, D. Vigo, P. Roccabianca, M. Caniatti, P. Moroni, F. Riva
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