Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates to Overcome Cancer Resistance

Articolo

Data di Pubblicazione:

2018

Citazione:

Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates to Overcome Cancer Resistance / G. Fumagalli, G. Giorgi, M. Vágvölgyi, E. Colombo, M. Christodoulou, V. Collico, D. Prosperi, F. Dosio, A. Hunyadi, M. Montopoli, M. Hyeraci, A. Silvani, G. Lesma, L.D. Via, D. Passarella. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 9:5(2018 Apr 17), pp. 468-471. [10.1021/acsmedchemlett.8b00078]

Abstract:

Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The in vitro cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.

Tipologia IRIS:

01 - Articolo su periodico

Keywords:

cancer; doxorubicin; drug toxicity; ecdysteroids; self-assembled-nanoparticles; biochemistry; drug discovery3003 pharmaceutical science; organic chemistry

Elenco autori: