Copper-catalyzed alkoxylation as key step to convert isatin to oxazinoindol-2-one derivatives
Articolo
Data di Pubblicazione:
2018
Citazione:
Copper-catalyzed alkoxylation as key step to convert isatin to oxazinoindol-2-one derivatives / M. Christodoulou, S. Giofrè, G. Broggini, L. Dalla Via, A. Mazza, E.M. Beccalli. - In: CHEMISTRYSELECT. - ISSN 2365-6549. - 3:16(2018 Apr 30), pp. 4361-4365. [10.1002/slct.201800568]
Abstract:
The treatment of N-alkyl-5,7-dibromoisatin derivatives through the copper-catalyzed sequential processes consisting of intra/intermolecular alkoxylation/amination or double alkoxylation provided the pyrrolo[1, 2,3-de]-1,4-benzoxazine derivatives. Moreover, the alkoxylation/arylation process proceeded in a one-pot fashion under tandem copper-palladium catalysis affording 5-(hetero)aryl substituted hetero-tricyclic systems. Biological evaluation of the synthesized compounds showed antiproliferative activity on the low micromolar range.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
alkoxylation; copper-catalysis; isatin; one-pot process; oxazinoindole; tandem Cu−Pd-catalysis; chemistry (all)
Elenco autori:
M. Christodoulou, S. Giofrè, G. Broggini, L. Dalla Via, A. Mazza, E.M. Beccalli
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