Study of the dosimetric robustness of PVA-GTA based Fricke gels against manufacture parameters=Studio della robustezza delle proprietà dosimetriche di gel di Fricke a matrice sintetica (PVA-GTA) dai parametri di fabbricazione
Abstract
Data di Pubblicazione:
2018
Citazione:
Study of the dosimetric robustness of PVA-GTA based Fricke gels against manufacture parameters=Studio della robustezza delle proprietà dosimetriche di gel di Fricke a matrice sintetica (PVA-GTA) dai parametri di fabbricazione / S. Gallo, G. Gambarini, L.C. Ianni', I. Veronese - In: Fisica Medica, un ponte tra presente e futuro[s.l] : AIFM, 2018 Apr 12. (( Intervento presentato al 10. convegno Congresso Nazionale AIFM tenutosi a Bari nel 2018.
Abstract:
Purpose: Fricke gel dosimeters (FGDs) based on poly-vinyl alcohol (PVA) as gelling agent and glutaraldehyde (GTA) as cross-linker, were developed with the aim to overcome the drawbacks affecting the FGDs prepared with traditional natural gel matrices like gelatin or agarose. Here, we investigate the dosimetric robustness of PVA-GTA FGDs against parameters influencing their preparation, like pH and temperature of gelling.
Materials and Methods: PVA-GTA matrices undergo gelling by heating instead of cooling. Gelling temperatures from 6°C to 40°C were considered. FGDs with PVA and GTA concentrations of 10% w/w and 1% w/w respectively, were arranged preparing Fricke solutions with different amounts of sulfuric acid in the interval 18-100 mM. FGDs in spectrophotometry cuvettes (10 mm optical path) were uniformly irradiated with a 137Cs source. The optical absorbance (OA) properties and dose-response in the interval 0-35 Gy were investigated. Furthermore, FGDs in form of thin layers (3 mm optical path, area 10x5 cm2) were irradiated with 80 kV X-rays producing a steep dose gradient. Light transmittance images were acquired before irradiation and at consecutive times up to 6 hours post-irradiation to derive the Fe3+ diffusion coefficient.
Results: OA spectra and dose-response curves of FGDs were independent of the gelling temperature. A sensitivity of approximately 0.073 Gy-1 was obtained. By contrast, as in traditional FGDs, sulfuric acid concentration significantly affected the OA spectra as well as the sensitivity and linearity of the PVA-GTA FGDs. Both gelling temperature gradient and pH did not influence the Fe3+ diffusion coefficient, assessed equal to approximately 0.22 mm2/h, i.e. more than two times lower than in traditional FGDs.
Conclusions: The robustness of PVA-GTA-FGDs against preparation parameters represent a significant advantage over traditional FGDs. In particular, the response independence of the gelling temperature may enable the manufacture of large FGD phantoms without any gradient in sensitivity.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Dosimetry; Fricke gel; PVA; GTA; Xylenolo Orange
Elenco autori:
S. Gallo, G. Gambarini, L.C. Ianni', I. Veronese
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Titolo del libro:
Fisica Medica, un ponte tra presente e futuro