Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: Our experience on 1,592 patients
Articolo
Data di Pubblicazione:
2017
Citazione:
Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: Our experience on 1,592 patients / D. Divisi, M. Barone, L. Bertolaccini, G. Rocco, P. Solli, R. Crisci, L. Ampollini, M. Alloisio, C. Andreetti, D. Amore, G. Baietto, A. Bandiera, C. Benato, D. Benetti, M. Benvenuti, A. Bertani, L. Bortolotti, E. Bottoni, P. Camplese, P. Carbognani, G. Cardillo, F. Carleo, C. Casadio, G. Cavallesco, C. Curcio, A. Denegri, G. Di Rienzo, G. Dolci, A. Droghetti, R. Gasparri, M. Ghisalberti, A. Gonfiotti, F. Guerrera, A. Imperatori, M. Infante, P. Lausi, F. Londero, C. Lopez, L. Luzzi, P. Maineri, P. Maniscalco, G. Marulli, M. Monteverde, A. Morelli, F. Mucilli, P. Natali, G. Negri, S. Nicotra, M. Nosotti, R. Perkmann, C. Poggi, F. Puma, M. Refai, A. Rinaldo, G. Rizzardi, L. Rosso, N. Rotolo, E. Russo, A. Sabatini, L. Spaggiari, A. Stefani, F. Stella, A. Terzi, M. Torre, D. Vinci, A. Viti, L. Voltolini, F. Zaraca. - In: JOURNAL OF THORACIC DISEASE. - ISSN 2072-1439. - 9:8(2017 Aug), pp. 2551-2559. [10.21037/jtd.2017.06.124]
Abstract:
Background: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut offfor malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion. Methods: A retrospective study on 1,592 SPN patients was carried out following approval by the Italian Registry of VATS Lobectomies. Results: All patients underwent VATS lobectomy. On histologic examination, 98.1% had primary or second metachronous primary lung cancers. In addition, 10.7% presented occult lymph node metastases (pN1 or pN2) on histological examination. Nodule attenuation on CT was associated with the histology of the lesion (p= 0.030); in particular, pure ground glass opacities (pGGOs) and partially solid nodules were related to adenocarcinomatous histotypes. Conversely, a significant relationship between SUVmax and age, nodule size, pathological node status (pN) was found (P=0.007, P=0.000 and P=0.002 respectively). Conclusions: Nodule attenuation can predict the histology of the lesion whereas SUVmax may relate to the propensity to lymph node metastases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ground glass opacities; Lung adenocarcinoma; Lymph node metastases; Maximum standardized uptake value; Solitary pulmonary nodule (SPN); Pulmonary and Respiratory Medicine
Elenco autori:
D. Divisi, M. Barone, L. Bertolaccini, G. Rocco, P. Solli, R. Crisci, L. Ampollini, M. Alloisio, C. Andreetti, D. Amore, G. Baietto, A. Bandiera, C. Benato, D. Benetti, M. Benvenuti, A. Bertani, L. Bortolotti, E. Bottoni, P. Camplese, P. Carbognani, G. Cardillo, F. Carleo, C. Casadio, G. Cavallesco, C. Curcio, A. Denegri, G. Di Rienzo, G. Dolci, A. Droghetti, R. Gasparri, M. Ghisalberti, A. Gonfiotti, F. Guerrera, A. Imperatori, M. Infante, P. Lausi, F. Londero, C. Lopez, L. Luzzi, P. Maineri, P. Maniscalco, G. Marulli, M. Monteverde, A. Morelli, F. Mucilli, P. Natali, G. Negri, S. Nicotra, M. Nosotti, R. Perkmann, C. Poggi, F. Puma, M. Refai, A. Rinaldo, G. Rizzardi, L. Rosso, N. Rotolo, E. Russo, A. Sabatini, L. Spaggiari, A. Stefani, F. Stella, A. Terzi, M. Torre, D. Vinci, A. Viti, L. Voltolini, F. Zaraca
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