Use of ACE inhibitors is associated with elevated levels of IGFBP-3 among hypertensive older adults : results from the IlSIRENTE study
Articolo
Data di Pubblicazione:
2007
Citazione:
Use of ACE inhibitors is associated with elevated levels of IGFBP-3 among hypertensive older adults : results from the IlSIRENTE study / G. Onder, R. Liperoti, A. Russo, E. Capoluongo, A. Minucci, P. Lulli, M. Cesari, M. Maggio, R. Bernabei, F. Landi. - In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0031-6970. - 63:4(2007), pp. 389-395. [10.1007/s00228-007-0262-z]
Abstract:
Objective: Several studies in vitro or in rodent models have suggested a potential relationship between angiotensin-converting enzyme (ACE) inhibition and the insulin-like growth factor 1 (IGF-1) axis. However, this relationship has only rarely been investigated in humans. The aim of the present cross-sectional study was to assess the association of ACE inhibitors with free IGF-1 and IGFBP-3 in the blood of older hypertensive adults. Methods: Data are from the baseline evaluation of the ilSIRENTE study, which enrolled 364 subjects aged 80 or older. For the present study we selected a subpopulation of 264 hypertensive participants without congestive heart failure. Free IGF-1 and IGFBP-3 in the blood were measured by a radioimmunoassay method. Analyses of covariance were performed to evaluate the differences in free IGF-1 and IGFBP-3 levels according to the use of ACE inhibitors. Results: The mean age of participants was 85.7 years (SD: 4.9), 170 (64%) were women and 123 (47%) were using an ACE inhibitor. Following adjustment for potential confounders, the concentration of free IGF-1 was slightly, but not significantly higher among ACE inhibitor users than among non-users (0.74 vs. 0.65 ng/mL; p=0.20). In contrast, ACE inhibitor users had a significantly higher IGFBP-3 serum levels than non-users (4821 vs. 4330 ng/mL; p=0.005). In addition, the concentration of IGFBP-3 was significantly higher among ACE inhibitors users than among non-users of antihypertensive drugs (p=0.02) and users of other antihypertensive drugs (p=0.01). Conclusion: Among hypertensive older adults, ACE inhibitors use is associated with higher IGFBP-3 levels.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ace inhibitors; Hypertension; IGF-1; IGFBP-3; Older adults; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Pharmacology; Pharmacology (medical)
Elenco autori:
G. Onder, R. Liperoti, A. Russo, E. Capoluongo, A. Minucci, P. Lulli, M. Cesari, M. Maggio, R. Bernabei, F. Landi
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