Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia : a pilot study
Articolo
Data di Pubblicazione:
2017
Citazione:
Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia : a pilot study / W. Timothy L, K. Robert R, F. Rafael, M. William A, A. Forest W, F. Stephen P, R. Marcos I, C. James D, P. Paula, C. Rodrigo, B. Jose, S. Aliberti, R. Julio A.. - In: THE UNIVERSITY OF LOUISVILLE JOURNAL OF RESPIRATORY INFECTIONS. - ISSN 2473-2869. - 1:1(2017). [10.18297/jri/vol1/iss1/1/]
Abstract:
Purpose: Patients with severe community-acquired pneumonia (CAP) are believed to have an exaggerated
inflammatory response to bacterial infection. Therapies aiming to modulate the inflammatory
response have been largely unsuccessful, perhaps reflecting that CAP is a heterogeneous
disorder that cannot be modulated by a single anti-inflammatory approach. We hypothesize that
the host inflammatory response to pneumonia may be characterized by distinct cytokine patterns,
which can be harnessed for personalized therapies.
Methods: Here, we use hierarchical cluster analysis of cytokines to examine if patterns of inflammatory
response in 13 hospitalized patients with CAP can be defined. This was a secondary data
analysis of the Community-Acquired Pneumonia Inflammatory Study Group (CAPISG) database.
The following cytokines were measured in plasma and sputum on the day of admission: interleukin
(IL)-1b, IL-1 receptor antagonist (IL-1ra), IL-6, CXCL8 (IL-8), IL-10, IL-12p40, IL-17, interferon
(IFN)g, tumor necrosis factor (TNF)a, and CXCL10 (IP-10). Hierarchical agglomerative
clustering algorithms were used to evaluate clusters of patients within plasma and sputum cytokine
determinations.
Results: A total of thirteen patients were included in this pilot study. Cluster analysis identified
distinct inflammatory response patterns of cytokines in the plasma, sputum, and the ratio of
plasma to sputum.
Conclusions: Inflammatory response patterns in plasma and sputum can be identified in hospitalized
patients with CAP. Characterization of the local and systemic inflammatory response
may help to better discriminate patients for enrollment into clinical trials of immunomodulatory
therapies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cytokines; immunomodulation; inflammatory response; outcomes; pneumonia; steroids
Elenco autori:
W. Timothy L, K. Robert R, F. Rafael, M. William A, A. Forest W, F. Stephen P, R. Marcos I, C. James D, P. Paula, C. Rodrigo, B. Jose, S. Aliberti, R. Julio A.
Link alla scheda completa: