Data di Pubblicazione:
2017
Citazione:
Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates / G. Fumagalli, B. Stella, I. Pastushenko, F. Ricci, M.S. Christodoulou, G. Damia, D. Mazza, S. Arpicco, C. Giannini, L. Morosi, F. Dosio, P.A. Sotiropoulou, D. Passarella. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 8:9(2017 Aug 01), pp. 953-957. [10.1021/acsmedchemlett.7b00262]
Abstract:
The preparation of hetero-nanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumour growth and toxicity of chemotherapy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cancer; cyclopamine; doxorubicin; drug toxicity; self-assembled-nanoparticles
Elenco autori:
G. Fumagalli, B. Stella, I. Pastushenko, F. Ricci, M.S. Christodoulou, G. Damia, D. Mazza, S. Arpicco, C. Giannini, L. Morosi, F. Dosio, P.A. Sotiropoulou, D. Passarella
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