Nomenclature and diagnosis of gluten-related disorders : a position statement by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO)
Articolo
Data di Pubblicazione:
2017
Citazione:
Nomenclature and diagnosis of gluten-related disorders : a position statement by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) / L. Elli, D. Villalta, L. Roncoroni, D. Barisani, S. Ferrero, N. Pellegrini, M.T. Bardella, F. Valiante, C. Tomba, A. Carroccio, M. Bellini, M. Soncini, R. Cannizzaro, G. Leandro. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 49:2(2017 Feb 01), pp. 138-146. [10.1016/j.dld.2016.10.016]
Abstract:
BACKGROUND:
"Gluten-related disorders" is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them.
AIM:
To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood.
METHODS:
The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest. Each member was assigned a task and levels of evidence/recommendation have been proposed.
RESULTS:
The panel identified celiac disease, wheat allergy and non-celiac gluten sensitivity as the gluten-related disorders of gastroenterological interest. Celiac disease has an autoimmune nature, wheat allergy is IgE-mediated while the pathogenesis of non-celiac gluten sensitivity is still unknown as is the case of non-IgE mediated allergy. Diagnosis should start with the serological screening for celiac disease and wheat allergy. In case of normal values, the response to a gluten-free diet should be evaluated and a confirmatory blind food challenge carried out.
CONCLUSIONS:
Gluten-related disorders are clinically heterogeneous. Patients should be carefully managed and specific protocols applied for a correct differential diagnosis in gastroenterological setting.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Celiac disease; Food allergy; Gluten-related disorders; Non-celiac gluten sensitivity; Wheat allergy
Elenco autori:
L. Elli, D. Villalta, L. Roncoroni, D. Barisani, S. Ferrero, N. Pellegrini, M.T. Bardella, F. Valiante, C. Tomba, A. Carroccio, M. Bellini, M. Soncini, R. Cannizzaro, G. Leandro
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