The lipopolysaccharide export pathway in Escherichia coli : structure, organization and regulated assembly of the Lpt machinery
Articolo
Data di Pubblicazione:
2014
Citazione:
The lipopolysaccharide export pathway in Escherichia coli : structure, organization and regulated assembly of the Lpt machinery / A. Polissi, P. Sperandeo. - In: MARINE DRUGS. - ISSN 1660-3397. - 12:2(2014), pp. 1023-1042. [10.3390/md12021023]
Abstract:
The bacterial outer membrane (OM) is a peculiar biological structure with a unique composition that contributes significantly to the fitness of Gram-negative bacteria in hostile environments. OM components are all synthesized in the cytosol and must, then, be transported efficiently across three compartments to the cell surface. Lipopolysaccharide (LPS) is a unique glycolipid that paves the outer leaflet of the OM. Transport of this complex molecule poses several problems to the cells due to its amphipatic nature. In this review, the multiprotein machinery devoted to LPS transport to the OM is discussed together with the challenges associated with this process and the solutions that cells have evolved to address the problem of LPS biogenesis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Escherichia coli; Lipopolysaccharide transport; Outer membrane; Bacterial Outer Membrane Proteins; Biological Transport; Cytosol; Escherichia coli; Escherichia coli Proteins; Lipopolysaccharides; Drug Discovery; Pharmaceutical Science
Elenco autori:
A. Polissi, P. Sperandeo
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