Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five
Articolo
Data di Pubblicazione:
2014
Citazione:
Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five / L. Cipolla, C. Airoldi, P. Sperandeo, S. Gianera, A. Polissi, F. Nicotra, L. Gabrielli. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 389:1(2014), pp. 186-191.
Abstract:
A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studies. The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and Escherichia coli strains. Unfortunately, none of the synthesised compounds was able neither to bind API nor to inhibit bacterial growth.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Arabinose 5-phosphate; NMR interaction studies; Phosphate analogues; Pseudomonas aeruginosa; Sugar isomerase; Aldose-Ketose Isomerases; Biomimetic Materials; Chemistry Techniques, Synthetic; Escherichia coli; Mutation; Pentosephosphates; Pseudomonas aeruginosa; Biochemistry; Analytical Chemistry; Organic Chemistry; Medicine (all)
Elenco autori:
L. Cipolla, C. Airoldi, P. Sperandeo, S. Gianera, A. Polissi, F. Nicotra, L. Gabrielli
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