Data di Pubblicazione:
1996
Citazione:
Cross-talk between the insulin and angiotensin signaling systems / L.A. Velloso, F. Folli, X.J. Sun, M.F. White, M.J.A. Saad, C.R. Kahn. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 93:22(1996), pp. 12490-12495.
Abstract:
Angiotensin II (AII), acting via its G-protein linked receptor, is an important regulator of cardiac, vascular, and renal function. Following injection of AII into rats, we find that there is also a rapid tyrosine phosphorylation of the major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart. This phenomenon appears to involve JAK2 tyrosine kinase, which associates with the AT1 receptor and IRS-1/IRS-2 after AII stimulation. AII-induced phosphorylation leads to binding of pbosphatidylinositol 3- kinase (PI 3-kinase) to IRS-1 and IRS-2; however, in contrast to other ligands, AII injection results in an acute inhibition of both basal and insulin-stimulated PI 3-kinase activity. The latter occurs without any reduction in insulin receptor or IRS phosphorylation or in the interaction of the p85 and p110 subunits of PI 3-kinase with each other or with IRS-1/IRS- 2. These effects of AII are inhibited by AT1 receptor antagonists. Thus, there is direct cross-talk between insulin and AII signaling pathways at the level of both tyrosine phosphorylation and PI 3-kinase activation. These interactions may play an important rule in the association of insulin resistance, hypertension, and cardiovascular disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
smooth-muscle cells; phosphatidylinositol 3-kinase; receptor substrate-1; tyrosine phosphorylation; protein-kinase; stimulation; activation; association; growth; heart
Elenco autori:
L.A. Velloso, F. Folli, X.J. Sun, M.F. White, M.J.A. Saad, C.R. Kahn
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