Modified quaternary ammonium salts as potential antimalarial agents

Academic Article
Publication Date:
2015
Citation:
Modified quaternary ammonium salts as potential antimalarial agents / N. Basilico, M. Migotto, D.P. Ilboudo, D. Taramelli, R. Stradi, E. Pini. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 23:15(2015 Aug), pp. 4681-4687.
abstract:
A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells.
IRIS type:
01 - Articolo su periodico
Keywords:
(2E,4E,6E)-Octatrien-1-ol; Antimalarial drugs; Malaria; P. falciparum; Quaternary ammonium salts; Antimalarials; Plasmodium falciparum; Quaternary Ammonium Compounds; Salts; Biochemistry; Clinical Biochemistry; Molecular Biology; Molecular Medicine; Organic Chemistry; Drug Discovery3003 Pharmaceutical Science; 3003; Medicine (all)
List of contributors:
N. Basilico, M. Migotto, D.P. Ilboudo, D. Taramelli, R. Stradi, E. Pini
Authors of the University:
BASILICO NICOLETTA ( author )
PINI ELENA RENATA ELVIRA ( author )
Link to information sheet:
https://air.unimi.it/handle/2434/459693

Research Areas

Concepts (2)