Efficient Synthesis of Spirooxindole-Fused 3-Thiazoline Derivatives by a One-Pot Asinger-Type Reaction
Articolo
Data di Pubblicazione:
2016
Citazione:
Efficient Synthesis of Spirooxindole-Fused 3-Thiazoline Derivatives by a One-Pot Asinger-Type Reaction / G. Rainoldi, F. Begnini, A. Silvani, G. Lesma. - In: SYNLETT. - ISSN 0936-5214. - 27:20(2016 Dec 15), pp. 2831-2835.
Abstract:
A one-pot, three-component reaction has been developed and successfully employed for the synthesis of biologically relevant, highly functionalized spirooxindole-fused 3-thiazoline derivatives. Starting from ammonia, three mercapto carbonyl components and a series of substituted isatins, products were obtained in good yields (24 examples), by following a simple and rapid protocol. The obtained thiazolines proved to be optimal substrates for further transformations, including the three-component Ugi–Joullié reaction.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
asinger; multicomponent reactions; oxindole; spiro compounds; thiazoline; Ugi–Joullié reaction; organic chemistry
Elenco autori:
G. Rainoldi, F. Begnini, A. Silvani, G. Lesma
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