A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis : A EUSTAR exploratory study
Articolo
Data di Pubblicazione:
2015
Citazione:
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis : A EUSTAR exploratory study / F. Ingegnoli, P. Boracchi, R. Gualtierotti, V. Smith, M. Cutolo, I. Foeldvari, P. Airo, J.J. Alegre-Sancho, Y. Allanore, L.P. Ananieva, C. Ancuta, L.E. Andrade, M. Aringer, R. Becvar, M. Bojinca, I. Butrimiene, F.P. Cantatore, R. Caporali, P. Caramaschi, P.E. Carreira, R. Chirieac, A. Corrado, V. Cosentino, G. Cuomo, L. Czirjak, J.A.P. Da Silva, P.G. de la Pena Lefebvre, F. De Keyser, C. de Souza Muller, K. Damgaard, N. Damjanov, L.N. Denisov, O. Distler, A. Doube, A. Dumitrascu, M. Engelhart, M.V. Exposito, K. Eyerich, D. Farge-Bancel, V.F. Azevedo, R. Foti, M. Frerix, A. Gabrielli, T. Garen, P. Gottschalk, L. Groseanu, S. Guiducci, C. Gunther, E. Hachulla, R. Hein, S. Heitmann, J. Henes, R. Hesselstrand, J. Highton, F. Iannone, R.M. Ionescu, C. Kayser, D. Karpec, E. Kerzberg, A. Kotulska, M. Kopec-Medrek, E. Kucharz, B. Krummel-Lorenz, F. Lauffer, D. Launay, M. Li, I. Litinsky, E. Loyo, M.M. Cerinic, P. Meroni, O. Midtvedt, C.M. Mihai, C. Montecucco, F. Montoya, E. Morgiel, L. Mouthon, U. Muller-Ladner, H. Nielsen, D. Opris, V. Ortiz-Santamaria, K. Otsa, M. Pileckyte, S. Pisarri, M. Popescu, M.R. Pozzi, F. Puppo, S.C. Radominski, V. Riccieri, E. Rosato, B. Rozman, S.R. Rubio, R. Rugiene, P. Saar, M.J. Salvador, M. Seidel, R. Sokolik, K. Solanki, B. Stamenkovic, A. Stankovic, S. Stebbings, G. Strauss, A. Sulli, S. Szamosi, J. Szechinski, M. Szmyrka-Kaczmarek, G. Szucs, C.-. Tanaseanu, I. Tiglea, A. Tyndall, N. Ughi, M. Uprus, A. Vacca, C. Varju, A. Venalis, P. Venalis, U.A. Walker, M. Widuchowska, P. Wiland, D. M. Wuttge, S. Zeni, T. Zenone. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 102(2015 Nov), pp. 19-24. [10.1016/j.mvr.2015.07.007]
Abstract:
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
capillaroscopy; eustar; juvenile systemic sclerosis; microcirculation; nailfold capillaroscopy; systemic sclerosis; videocapillaroscopy; adolescent; adult; age of onset; aged; capillaries; child; female; humans; male; microscopic angioscopy; middle aged; retrospective studies; scleroderma, localized; scleroderma, systemic; young adult; biochemistry; cardiology and cardiovascular medicine; cell biology
Elenco autori:
F. Ingegnoli, P. Boracchi, R. Gualtierotti, V. Smith, M. Cutolo, I. Foeldvari, P. Airo, J.J. Alegre-Sancho, Y. Allanore, L.P. Ananieva, C. Ancuta, L.E. Andrade, M. Aringer, R. Becvar, M. Bojinca, I. Butrimiene, F.P. Cantatore, R. Caporali, P. Caramaschi, P.E. Carreira, R. Chirieac, A. Corrado, V. Cosentino, G. Cuomo, L. Czirjak, J.A.P. Da Silva, P.G. de la Pena Lefebvre, F. De Keyser, C. de Souza Muller, K. Damgaard, N. Damjanov, L.N. Denisov, O. Distler, A. Doube, A. Dumitrascu, M. Engelhart, M.V. Exposito, K. Eyerich, D. Farge-Bancel, V.F. Azevedo, R. Foti, M. Frerix, A.M. CARVALHAS GABRIELLI, T. Garen, P. Gottschalk, L. Groseanu, S. Guiducci, C. Gunther, E. Hachulla, R. Hein, S. Heitmann, J. Henes, R. Hesselstrand, J. Highton, F. Iannone, R.M. Ionescu, C. Kayser, D. Karpec, E. Kerzberg, A. Kotulska, M. Kopec-Medrek, E. Kucharz, B. Krummel-Lorenz, F. Lauffer, D. Launay, M. Li, I. Litinsky, E. Loyo, M.M. Cerinic, P. Meroni, O. Midtvedt, C.M. Mihai, C. Montecucco, F. Montoya, E. Morgiel, L. Mouthon, U. Muller-Ladner, H. Nielsen, D. Opris, V. Ortiz-Santamaria, K. Otsa, M. Pileckyte, S. Pisarri, M. Popescu, M.R. Pozzi, F. Puppo, S.C. Radominski, V. Riccieri, E. Rosato, B. Rozman, S.R. Rubio, R. Rugiene, P. Saar, M.J. Salvador, M. Seidel, R. Sokolik, K. Solanki, B. Stamenkovic, A. Stankovic, S. Stebbings, G. Strauss, A. Sulli, S. Szamosi, J. Szechinski, M. Szmyrka-Kaczmarek, G. Szucs, C.-. Tanaseanu, I. Tiglea, A. Tyndall, N. Ughi, M. Uprus, A. Vacca, C. Varju, A. Venalis, P. Venalis, U.A. Walker, M. Widuchowska, P. Wiland, D. M. Wuttge, S. Zeni, T. Zenone
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