Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study
Articolo
Data di Pubblicazione:
2016
Citazione:
Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study / S. Aliberti, L.F. Reyes, P. Faverio, G. Sotgiu, S. Dore, A.H. Rodriguez, N.J. Soni, M.I. Restrepo. - In: THE LANCET INFECTIOUS DISEASES. - ISSN 1473-3099. - 16:12(2016 Dec 01), pp. 1364-1376. [10.1016/S1473-3099(16)30267-5]
Abstract:
Background Antibiotic resistance is a major global health problem and pathogens such as meticillin-resistant
Staphylococcus aureus (MRSA) have become of particular concern in the management of lower respiratory tract
infections. However, few data are available on the worldwide prevalence and risk factors for MRSA pneumonia.
We aimed to determine the point prevalence of MRSA pneumonia and identify specifi c MRSA risk factors in
community-dwelling patients hospitalised with pneumonia.
Methods We did an international, multicentre study of community-dwelling, adult patients admitted to hospital
with pneumonia who had microbiological tests taken within 24 h of presentation. We recruited investigators from
222 hospitals in 54 countries to gather point-prevalence data for all patients admitted with these characteristics
during 4 days randomly selected during the months of March, April, May, and June in 2015. We assessed prevalence
of MRSA pneumonia and associated risk factors through logistic regression analysis.
Findings 3702 patients hospitalised with pneumonia were enrolled, with 3193 patients receiving microbiological
tests within 24 h of admission, forming the patient population. 1173 (37%) had at least one pathogen isolated
(culture-positive population). The overall prevalence of confi rmed MRSA pneumonia was 3·0% (n=95), with
diff ering prevalence between continents and countries. Three risk factors were independently associated with
MRSA pneumonia: previous MRSA infection or colonisation (odds ratio 6·21, 95% CI 3·25–11·85), recurrent skin
infections (2·87, 1·10–7·45), and severe pneumonia disease (2·39, 1·55–3·68).
Interpretation This multicountry study shows low prevalence of MRSA pneumonia and specifi c MRSA risk factors
among community-dwelling patients hospitalised with pneumonia.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Aliberti, L.F. Reyes, P. Faverio, G. Sotgiu, S. Dore, A.H. Rodriguez, N.J. Soni, M.I. Restrepo
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