Prevalence of Cardiovascular Disease and Osteoporosis During Androgen Deprivation Therapy Prescription Discordant to EAU Guidelines : Results From a Multicenter, Cross-sectional Analysis From the CHOsIng Treatment for Prostate canCEr (CHOICE) Study
Articolo
Data di Pubblicazione:
2016
Citazione:
Prevalence of Cardiovascular Disease and Osteoporosis During Androgen Deprivation Therapy Prescription Discordant to EAU Guidelines : Results From a Multicenter, Cross-sectional Analysis From the CHOsIng Treatment for Prostate canCEr (CHOICE) Study / G. Morgia, G.I. Russo, A. Tubaro, R. Bortolus, D. Randone, P. Gabriele, F. Trippa, F. Zattoni, M. Porena, V. Mirone, S. Serni, A. Del Nero, G. Lay, U. Ricardi, F. Rocco, C. Terrone, A. Pagliarulo, G. Ludovico, G. Vespasiani, M. Brausi, C. Simeone, G. Novella, G. Carmignani, R. Leonardi, P. Pinnarò, U. De Paula, R. Corvò, R. Tenaglia, S. Siracusano, G. Mantini, P. Gontero, G. Savoca, V. Ficarra. - In: UROLOGY. - ISSN 0090-4295. - 96:Special Issue(2016 Oct), pp. 165-170. [10.1016/j.urology.2016.06.024]
Abstract:
OBJECTIVE To analyze the prevalence of cardiovascular disease (CVD) and osteoporosis in patients treated
with androgen deprivation therapy (ADT) for prostate cancer (PCa) but not adherent to European
Association of Urology (EAU) guidelines.
MATERIALS AND
METHODS
The CHOosIng Treatment for Prostate CanCEr (CHOICE) study was an Italian multicenter, crosssectional
study conducted from December 2010 to January 2012. A total of 1386 patients treated
with ADT for PCa (first prescription or renewal of ADT) were selected. According to EAU guidelines,
the cohort was categorized in discordant ADT (Group A) and concordant ADT (Group B). The prevalence of CVD and osteoporosis after ADT was recorded. RESULTS
The final cohort included 1075 patients. According to EAU guidelines adherence, 285 (26.51%)
and 790 (73.49%) were considered discordant and concordant, respectively. The proportion of
men with Charlson Comorbidity Index
>2 at baseline was statistically similar in Group A (81.8%)compared to Group B (80.8%) (P= .96). The number of complications reported at enrollment was as follows: cardiovascular in 351 (32.7%), endocrine in 166 (15.4%), sexual in 498 (46.3%),
osteoporosis in 181 (16.8%), and gynecomastia in 274 (25.5%) subjects. At the multivariate lo-
gistic regression analysis adjusted for confounding factors, discordant ADT was associated with
greater risk of cardiovascular complications (odds ratio: 2.07; P<.01) and osteoporosis (odds ratio: 1.75; P = .04).
CONCLUSION
About one-third of patients with PCa received inappropriate ADT and showed a greater risk of
CVD and osteoporosis. These results could be useful for setting better policy strategies to limit
the inappropriateness of ADT prescription.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Morgia, G.I. Russo, A. Tubaro, R. Bortolus, D. Randone, P. Gabriele, F. Trippa, F. Zattoni, M. Porena, V. Mirone, S. Serni, A. Del Nero, G. Lay, U. Ricardi, F. Rocco, C. Terrone, A. Pagliarulo, G. Ludovico, G. Vespasiani, M. Brausi, C. Simeone, G. Novella, G. Carmignani, R. Leonardi, P. Pinnarò, U. De Paula, R. Corvò, R. Tenaglia, S. Siracusano, G. Mantini, P. Gontero, G. Savoca, V. Ficarra
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