Cinetica e biodisponibilita' del naproxene nel cavallo sportivo

The kinetics of naproxen (NSAIDs), orally (OS) administered at the daily dose of 10 mg.kg-1 repeated for 5 consecutive days, was investigated in 5 healthy race-horses. The kinetics was described by a monocompartimental model. The drug showed an elimination half-life of 6.48 hours (T1/2el); the peak concentration (mean Cmax = 38.62 mcg.ml-1) was attained in about 3.25 hours (mean Tmax); the clearance (mean value) was 0.020 L.h-1.kg-1. The bioavailability (F = 89.31%) was calculated by comparing the oral AUC values and the intravenous AUC values (data reported in a previous paper).