Process for obtaining non-allergic propolis

The present invention relates to a process for pre-treating raw propolis comprising at least one allergenic activity substance, which comprises reacting propolis with a probiotic microorganism containing one or more cinnamoyl- esterase activity enzymes to obtain a semisolid propolis derivative substantially without or impoverished of allergenic substances. The present invention also relates to a method of purifying semisolid propolis derivative to obtain a hydroalcoholic hydrodispersible propolis derivative.