High dose chemotherapy with autologous hematopoietic stem cell support for solid tumors other than breast cancer in adults
Articolo
Data di Pubblicazione:
2006
Citazione:
High dose chemotherapy with autologous hematopoietic stem cell support for solid tumors other than breast cancer in adults / P. Pedrazzoli, J.A. Ledermann, J.-. Lotz, S. Leyvraz, M. Aglietta, G. Rosti, K.M. Champion, S. Secondino, F. Selle, N. Ketterer, G. Grignani, S. Siena, T. Demirer. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 17:10(2006), pp. 1479-1488. [10.1093/annonc/mdl044]
Abstract:
Since the early 1980s high dose chemotherapy with autologous hematopoietic stem cell support was adopted by many oncologists as a potentially curative option for solid tumors, supported by a strong rationale from laboratory studies and apparently convincing results of early phase II studies. As a result, the number and size of randomized trials comparing this approach with conventional chemotherapy initiated (and often abandoned before completion) to prove or disprove its value was largely insufficient. In fact, with the possible exception of breast carcinoma, the benefit of a greater escalation of dose of chemotherapy with stem cell support in solid tumors is still unsettled and many oncologists believe that this approach should cease. In this article, we critically review and comment on the data from studies of high dose chemotherapy so far reported in adult patients with small cell lung cancer, ovarian cancer, germ cell tumors and sarcomas.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
high dose chemotherpy; solid tumors; stem cell transplantation
Elenco autori:
P. Pedrazzoli, J.A. Ledermann, J.-. Lotz, S. Leyvraz, M. Aglietta, G. Rosti, K.M. Champion, S. Secondino, F. Selle, N. Ketterer, G. Grignani, S. Siena, T. Demirer
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