Natural molecules with regenerative potential for salivary gland disorders

The major function of the salivary glands is to secrete saliva, which plays a significant role in lubrication, digestion, immunity, and the overall maintenance of homeostasis within the human body.Development of the salivary glands begins during the sixth to eighth embryonic week when oral ectodermal outpouchings extend into the adjacent mesoderm and serve as the site of origin for major salivary gland growth. Salivary glands may be affected by heterogeneous disorders, ranging from autoimmune to metabolic diseases. Many therapeutic approaches are employed to face salivary gland disorders, which include stem cell regenerative potentials. Most innovative studies also show a significative ability of natural compounds, among which flavonoids, polyphenols and fatty acids, in regenerating affected salivary glands thanks to their anti-oxidant, anti-apoptotic, anti-inflammatory and pro-angiogenic effects.