Composition, cytotoxic and antimicrobial activities of Satureja intermedia C.A.Mey essential oil
Articolo
Data di Pubblicazione:
2015
Citazione:
Composition, cytotoxic and antimicrobial activities of Satureja intermedia C.A.Mey essential oil / J. Sharifi-Rad, M. Sharifi-Rad, S.M. Hoseini-Alfatemi, M. Iriti, M. Sharifi-Rad, M. Sharifi-Rad. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 16:8(2015 Aug 03), pp. 17812-17825.
Abstract:
In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were γ-terpinene (37.1%), thymol (30.2%), p-cymene (16.2%), limonene (3.9%), α-terpinene (3.3%), myrcene (2.5%), germacrene B (1.4%), elemicine (1.1%) and carvacrol (0.5%). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p < 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Breast adenocarcinoma; GC/MS; Hepatocellular carcinoma; Human cancer cells; Oral pathogens; Physical and Theoretical Chemistry; Organic Chemistry; Spectroscopy; Inorganic Chemistry; Catalysis; Molecular Biology; Computer Science Applications1707 Computer Vision and Pattern Recognition
Elenco autori:
J. Sharifi-Rad, M. Sharifi-Rad, S.M. Hoseini-Alfatemi, M. Iriti, M. Sharifi-Rad, M. Sharifi-Rad
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