Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas)

Articolo

Data di Pubblicazione:

2015

Citazione:

Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas) / R. Guardado Mendoza, C. Perego, G. Finzi, S. La Rosa, C. Capella, L.M. Jimenez-Ceja, L.A. Velloso, M.J.A. Saad, F. Sessa, F. Bertuzzi, S. Moretti, E.J. Dick, A.M. Davalli, F. Folli. - In: DIABETOLOGIA. - ISSN 1432-0428. - 58:8(2015 Aug), pp. 1814-1826. [10.1007/s00125-015-3625-5]

Abstract:

The cellular composition of the islet of Langerhans is essential to ensure its physiological function. Morphophysiological islet abnormalities are present in type 2 diabetes but the relationship between fasting plasma glucose (FPG) and islet cell composition, particularly the role of delta cells, is unknown. We explored these questions in pancreases from baboons (Papio hamadryas) with FPG ranging from normal to type 2 diabetic values.

Tipologia IRIS:

01 - Articolo su periodico

Keywords:

Islet of Langerhans; diabetes; somatostatin; apoptosis; pancreas; insulin

Elenco autori: