Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to prias criteria
Articolo
Data di Pubblicazione:
2016
Citazione:
Multicenter analysis of pathological outcomes of patients eligible for active surveillance according to prias criteria / A.A. Grasso, G. Cozzi, E. De Lorenzis, C. Ceruti, S. Crivellaro, M. Falsaperla, A. Minervini, L. Masieri, S. Serni, A. Porreca, S. Zaramella, B. Rocco. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - 3:3(2016 Jun), pp. 237-241.
Abstract:
AIM:
To retrospectively analyze the pathological outcomes of patients meeting the Prostate Cancer Research International Active Surveillance (PRIAS) criteria who had undergone radical prostatectomy (RP).
PATIENTS AND METHODS:
Out of 2014 patients recruited for minimally invasive RP between 2008 and 2014 in 7 centers, 226 (11.2%) met the modified PRIAS criteria (clinical stage T1c/T2, PSA <10 ng/ml, 1--2 positive biopsy cores and Gleason score < 6).
RESULTS:
At pathological evaluation, Gleason score upgrade was reported in 47.3% of patients; 74 (32.7%), 10 (4.4%), 9 (3.9%) patients showed RP Gleason sum 7, 8 and 9, respectively. Upstaging was reported in 135 patients (59.7%). 12 (5.3%) and 4 (1.7 %) patients had T3a and T3b pathological stage respectively.
CONCLUSIONS:
Notwithstanding the PRIAS criteria can identify some PCa patients as low--risk, at pathological evaluation some of them harbored intermediate-- or high--risk disease. According to our data, patients eligible for AS should be carefully counseled about possible disease understaging.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A.A. Grasso, G. Cozzi, E. De Lorenzis, C. Ceruti, S. Crivellaro, M. Falsaperla, A. Minervini, L. Masieri, S. Serni, A. Porreca, S. Zaramella, B. Rocco
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