Data di Pubblicazione:
2015
Citazione:
About estimating the limit of detection by the signal to noise approach / E. Desimoni, B. Brunetti. - In: PHARMACEUTICA ANALYTICA ACTA. - ISSN 2153-2435. - 6:3(2015), pp. 1-4. [10.4172/2153-2435.1000355]
Abstract:
The limit of detection (LOD) is an important figure of merit estimated in validation studies or when reporting
the performances of an analytical method. While the very meaning of LOD is clear to anyone, its estimation is still
matter of discussion. This explains the plethora of available approaches. However, the most popular are generally
the simplest ones. Between these, it is worth mentioning the approach based on the signal to noise (S/N) ratio,
included among those suggested by international guidelines such asthe United States Pharmacopeia, the European
Pharmacopoeia and others. This contribution attempts evaluating if this approach could be replaced by that based
on the standard error of estimate, sy/x.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Signal to noise ratio; Limit of detection; Standard error of the regression; Chromatographic/Voltammetric/Spectroscopic signals
Elenco autori:
E. Desimoni, B. Brunetti
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