Supported chiral organocatalyst for stereoselective reactions under batch and continuous flow conditions

Chiral primary amines derived from cinchona alkaloids represent a well-established class of stereoselective organocatalysts capable of promoting a great number of chemical transformations with excellent levels of enantioselectivity. Their immobilization onto a polymeric support is an attractive procedure to develop an easily recyclable heterogeneous catalytic system. The supported catalyst proved to be very efficient, versatile and well comparable to the corresponding non-supported one. The confinement of supported catalyst into flow reactors represents an intriguing methodology to perform stereoselective reactions in continuo.