Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress : a pilot registry study
Articolo
Data di Pubblicazione:
2015
Citazione:
Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress : a pilot registry study / G. Belcaro, U. Cornelli, R. Luzzi, A. Ledda, M. Cacchio, A. Saggino, M. Cesarone, M. Dugall, B. Feragalli, S. Hu, L. Pellegrini, E. Ippolito. - In: JOURNAL OF NEUROSURGICAL SCIENCES. - ISSN 0390-5616. - 59:2-3(2015 Jan), pp. 105-117.
Abstract:
AIM:
The aim of this registry study was to evaluate the effects of supplementation with Robuvit® (French Quercus robur extract) capsules in subjects with Chronic Fatigue Syndrome (CFS) associated with an increased oxidative stress. Robuvit is a wood extract from Quercus robur (Horphag Research) used to improve liver dysfunction and chronic fatigue. After excluding any disease, subjects observed a defined management plan to improve CFS. Signs/symptoms had been present for more than 6 months in association with an increase in oxidative stress (measured as plasma free radicals). Blood tests were within normal values.
METHODS:
The registry study included 38 CFS subjects and 42 comparable controls. There were no dropouts in the 4 weeks of follow-up; the subjects were evaluated for a further period of 6 months. The management plan included: improved/increased sleep; reduction/abolition in smoking and alcohol or any other agent that may have affected them; control of diet, increase in dietary proteins; good hydration; rest (1/2-1 h/day) and exercise (at least 30 min/day); planned relaxation time; increased time in open spaces. In the Robuvit® supplementation group 300 mg/day of Robuvit® was used.
RESULTS:
Symptoms improved in both groups with a significantly more important improvement in the supplement group (P<0.05). The single items in the Multidimensional Assessment of Fatigue (MAF) questionnaire were statistically better improved (P<0.05) in the supplement group. A parallel improvement in oxidative stress was observed in the supplemented subjects. In the follow up, at 6 months no organic disease was discovered or disease markers found.
CONCLUSION:
This preliminary registry indicates that supplementation with Robuvit® improves CFS in otherwise healthy subjects with no presence of clinical disease or risk conditions. The effects of Robuvit® in CFS may be partially mediated by a clear reduction of plasma free radicals and oxidative stress.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Fatigue syndrome, chronic; Oxidative stress; Free radicals; Fatigue
Elenco autori:
G. Belcaro, U. Cornelli, R. Luzzi, A. Ledda, M. Cacchio, A. Saggino, M. Cesarone, M. Dugall, B. Feragalli, S. Hu, L. Pellegrini, E. Ippolito
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