Skip to Main Content (Press Enter)

Logo UNIMI
  • ×
  • Home
  • Persone
  • Attività
  • Ambiti
  • Strutture
  • Pubblicazioni
  • Terza Missione

Expertise & Skills
Logo UNIMI

|

Expertise & Skills

unimi.it
  • ×
  • Home
  • Persone
  • Attività
  • Ambiti
  • Strutture
  • Pubblicazioni
  • Terza Missione
  1. Pubblicazioni

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

Articolo
Data di Pubblicazione:
2014
Citazione:
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner / M. Elgendy, M. Ciro, A.K. Abdel Aziz, G. Belmonte, R. Dal Zuffo, C. Mercurio, C. Miracco, L. Lanfrancone, M. Foiani, S. Minucci. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 5:(2014), pp. 5637.1-5637.11. [10.1038/ncomms6637]
Abstract:
Mcl-1 is a unique Bcl-2 family member that plays crucial roles in apoptosis. Apoptosis-unrelated functions of Mcl-1 are however emerging, further justifying its tight regulation. Here we unravel a novel mechanism of Mcl-1 regulation mediated by the haplo-insufficient tumour suppressor Beclin 1. Beclin 1 negatively modulates Mcl-1 stability in a reciprocal manner whereby depletion of one leads to the stabilization of the other. This co-regulation is independent of autophagy and of their physical interaction. Both Beclin 1 and Mcl-1 are deubiquitinated and thus stabilized by binding to a common deubiquitinase, USP9X. Beclin 1 and Mcl-1 negatively modulate the proteasomal degradation of each other through competitive displacement of USP9X. The analysis of patient-derived melanoma cells and tissue samples shows that the levels of Beclin 1 decrease, while Mcl-1 levels subsequently increase during melanoma progression in a significant inter-dependent manner. The identified inverse co-regulation of Beclin 1 and Mcl-1 represents a mechanism of functional counteraction in cancer.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
targeting MCL-1; prostate-cancer; melanoma-cells; apoptosis; expression; resistance; survival; therapy; inhibition; sabutoclax
Elenco autori:
M. Elgendy, M. Ciro, A.K. Abdel Aziz, G. Belmonte, R. Dal Zuffo, C. Mercurio, C. Miracco, L. Lanfrancone, M. Foiani, S. Minucci
Autori di Ateneo:
FOIANI MARCO ( autore )
MINUCCI SAVERIO ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/257707
Link al Full Text:
https://air.unimi.it/retrieve/handle/2434/257707/666958/ncomms6637.pdf
  • Aree Di Ricerca

Aree Di Ricerca

Settori


Settore BIO/11 - Biologia Molecolare
  • Informazioni
  • Assistenza
  • Accessibilità
  • Privacy
  • Utilizzo dei cookie
  • Note legali

Realizzato con VIVO | Progettato da Cineca | 25.6.0.0