Data di Pubblicazione:
1997
Citazione:
Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation / N. Basilico, D. Monti, P. Olliaro, D. Taramelli. - In: FEBS LETTERS. - ISSN 0014-5793. - 409:2(1997 Jun 09), pp. 297-299. [10.1016/S0014-5793(97)00533-4]
Abstract:
Infrared spectroscopy was used to evaluate the effect of non-iron porphyrins (protoporphyrin IX and haematoporphyrin) on haematin polymerisation to beta-haematin at acidic pH. Both molecules effectively inhibited the reaction, with haematoporphyrin 6 times as active as protoporphyrin IX. We postulated that the interaction between the pi electron system of porphyrin rings leads to the formation of pi-pi adducts, which inhibit polymer elongation in the same way as antimalarial drugs (e.g., chloroquine); the presence of hydroxyl groups able to bind haem iron enhances activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
antimalarials; chloroquine; dimerization; hematoporphyrins; hemeproteins; hemin; humans; malaria, falciparum; polymers; protoporphyrins; spectroscopy, fourier transform Infrared
Elenco autori:
N. Basilico, D. Monti, P. Olliaro, D. Taramelli
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