Carboplatin plus etoposide in heavily pretreated castration-resistant prostate cancer patients
Articolo
Data di Pubblicazione:
2014
Citazione:
Carboplatin plus etoposide in heavily pretreated castration-resistant prostate cancer patients / C. Buonerba, P. Federico, D. Bosso, L. Puglia, T. Policastro, M. Izzo, F. Perri, G.D.V. Scarpati, M. Ferro, O. De Cobelli, S. De Placido, M. Aieta, C. Imbimbo, N. Longo, G. Di Lorenzo. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 10:8(2014), pp. 1353-1360. [10.2217/fon.14.71]
Abstract:
Aims: Carboplatin plus etoposide has modest efficacy in docetaxel-pretreated castration-resistant prostate cancer patients. We hypothesized that carboplatin-etoposide could still exert some therapeutic activity after docetaxel, cabazitaxel and either abiraterone or enzalutamide. Patients & methods: We enrolled 15 patients in the first step of a Phase II trial. The target sample size is 46 patients. The primary end point of the study was progression-free survival after 12 weeks. Results: The median progression-free survival was 11 weeks (range: 8-18), while median overall survival was 18 weeks (range: 12-26). Of seven patients with measurable disease, two had a partial response, two showed stable disease and the remaining three had progressive disease as the best radiological response. Five patients were considered progression-free after 12 weeks, prompting continuation of the trial. Conclusion: Our preliminary findings support the hypothesis that carboplatin plus etoposide may yield some clinical benefit in a population of patients who failed all currently approved therapeutic options for prostate cancer. © 2014 Future Medicine Ltd.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
abiraterone ; carboplatin ; enzalutamide ; etoposide ; neuroendocrine ; prostate cance r; Oncology ; Cancer Research
Elenco autori:
C. Buonerba, P. Federico, D. Bosso, L. Puglia, T. Policastro, M. Izzo, F. Perri, G.D.V. Scarpati, M. Ferro, O. De Cobelli, S. De Placido, M. Aieta, C. Imbimbo, N. Longo, G. Di Lorenzo
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