Iatrogenic Cushing's syndrome and topical steroid therapy : case series and review of the literature
Articolo
Data di Pubblicazione:
2014
Citazione:
Iatrogenic Cushing's syndrome and topical steroid therapy : case series and review of the literature / S. Decani, V. Federighi, E. Baruzzi, A. Sardella, G. Lodi. - In: THE JOURNAL OF DERMATOLOGICAL TREATMENT. - ISSN 0954-6634. - 25:6(2014), pp. 495-500. [Epub ahead of print] [10.3109/09546634.2012.755252]
Abstract:
Topical corticosteroids are considered first-line therapy in patients with chronic inflammatory oral mucosal diseases; among them, clobetasol propionate is one of the most widely used in oral medicine. Under physiological conditions, the transmucosal application is characterized by a significantly greater absorption than the skin application. Contrary to many publications about the side effects of topical corticosteroids in dermatology, few studies have investigated the systemic effects due to local application of these drugs on oral mucosa. Although topical steroid therapy for the management of oral diseases is generally associated with local adverse effects (candidiasis, stomatopyrosis, and hypogeusia), these drugs can also lead to systemic side effects, such as suppression of the hypothalamic-pituitary-adrenal axis and Cushing's syndrome. This review reports five cases of systemic adverse effects caused by clobetasol propionate topical treatment.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
topical steroid therapy ; iatrogenic Cushing's syndrome ; adverse effects ; autoimmune oral mucous membrane diseases
Read More: http://informahealthcare.com/doi/abs/10.3109/09546634.2012.755252
Elenco autori:
S. Decani, V. Federighi, E. Baruzzi, A. Sardella, G. Lodi
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